Celsense Products - Cell Sense

The Cell Sense product is an MRI tracer reagent that is readily taken up by cells in culture. When labeled cells are transferred to the living subject, Cell Sense is a long-lived cell tracking marker. In the laboratory, the reagent has been demonstrated to label a variety of cell types in culture. Cell Sense is used to track in real-time the delivery, migration, duration, and quantity of transplanted cells in vivo.

MRI using Cell Sense tracer reagent in living mouse. Images of transplanted cells are displayed in hot-iron scale and the anatomy in grayscale, showing transplanted cells in their anatomical context.

Example of Cell Sense in clinical applications. Cells of interest are cultured ex vivo along with the Cell Sense fluorochemical nanoparticles, resulting in intracellular uptake. The labeled cells are then inoculated into a test subject and imaged using MRI. Images of both the 19F (labeled cells) and 1H (background anatomy) channels are acquired in the same imaging sessions. A composite image is then constructed showing the regions containing labeled cells (shown in red) in their anatomical context.