Celsense Products - V-Sense

 

 

Celsense Products - V-Sense


Conventional approaches for scoring inflammation in animal tissue, such as histology, often lead to bottlenecks in the discovery and preclinical stages of therapeutic research. V-Sense is an enabling reagent used to accelerate the detection and quantification of inflammation. It can minimize the use of laborious histological processing and yield accurate, fast, and quantitative measures of inflammation in intact tissues or in vivo. V-Sense is a fluorine-based ‘tracer’ agent used in conjunction with nuclear magnetic resonance (NMR) or magnetic resonance imaging (MRI) instrumentation. The heart of V-Sense is a proprietary emulsion containing tiny perfluorocarbon droplets. V-Sense is safe for direct intravenous injection into animals. Following injection, the emulsion droplets are taken up by circulating leukocytes. The fluorine-tagged cells participate in any inflammatory event in vivo. When labeled cells accumulate at a site of inflammation, they become detectable using fluorine-19 (19F) NMR in excised tissue (via biopsy or necropsy) or by in vivo MRI. Quantification of the 19F signal yields a fast, accurate marker of the degree of inflammation present. V-Sense can be used to detect a wide range of lesions and diseases where inflammation is a hallmark, such as in cancer, cardiovascular disease, autoimmune disease, infectious pathogens, and injury.

 

V-Sense is used to rapidly detect and score inflammation in tissues. V-Sense labels inflammatory cells in vivo, accelerating preclinical studies. Visualization and quantification of inflammation ‘hot-spots’ is performed using 19F MRI, and conventional 1H images provide an anatomical roadmap. Voxel Tracker™ software fuses and displays 19F/1H images, and powerful, built-in analysis algorithms calculate inflammation severity in regions of interest. Alternatively, conventional liquid-state NMR is used to rapidly assay inflammation in panels of intact tissue specimens.

For addition information about V-Sense see:

V-Sense: A Versatile Reagent to Accelerate the Quantification of Inflammation in Tissue (PDF)